SOP for Operation and Calibration of pH Meter
STANDARD OPERATING PROCEDURE Operation and Calibration of pH Meter 1.0 Purpose To describe the standardized procedure for operation, calibration, and verification of the pH meter using USP buffer solutions to ensure accurate pH measurement in accordance with USP <791>, IP, BP, and EP. 2.0 Scope This SOP applies to all pH meters used in the Quality Control Laboratory for analysis of raw materials, intermediates, and finished pharmaceutical products. 3.0 Responsibility Designation Responsibility QC Analyst Operation, calibration, verification, slope check, and documentation QC Supervisor Review and verification of results QC Manager Overall compliance and approval Engineering Maintenance and servicing 4.0 Accountability The QC Manager is accountable for implementation and compliance with this SOP. 5.0 References USP <791> pH Indian Pharmacopoeia British Pharmacopoeia European Pharmacopoeia 2.2.3 pH Meter Manufacture...